Molecular Mechanisms of Human Disease
Mukhopadhyay Lab at UT AUSTIN
Research Interest: The focus of our studies is to understand the cell biology of human disease. Currently, we have two major projects:
1. Parkinsonism and metal homeostasis: Metals, such as iron, manganese, and copper, are essential for life, but become toxic at elevated levels and cause severe neurological diseases, such as parkinsonism. A major goal is to understand the mechanisms by which cells and organisms maintain homeostatic control of essential metals, and by which changes in these homeostatic pathways, secondary to genetic or environmental insults, lead to parkinsonism.
2. Intracellular trafficking of Shiga and related bacterial toxins: Bacteria that produce Shiga and related toxins affect millions each year. Antidotes for these toxins are not available, and this severely limits treatment options. The goal of this project is to determine the mechanisms by which these bacterial toxins invade cells to cause diease, and to design therapeutically viable small molecule inhibitors of toxin transport.
1. NIH/NIEHS R01;
2. NIH/NIEHS K99/R00.
Graduate program affiliations:
1. Pharmaceutical Sciences (Division of Pharmacology and Toxicology);
2. Cell and Molecular Biology (Institute for Cellular and Molecular Biology);
3. Biochemistry (Institute for Cellular and Molecular Biology);
4. Neuroscience (Institute for Neuroscience).